Calculated MW: 64
Specificity/Sensitivity: This antibody was raised against mouse BEST1 Extracellular domain.
Form: Liquid
Buffer (with preservative): PBS, 1% BSA, 0.05% Sodium Azide.
Concentration: 0.8 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
Uniprot ID: O88870
Antigen Species: Mouse
Immunogen: Peptide (C)NPNKDYPGHEMD, corresponding to amino acid residues 259-270 of mouse Bestrophin-1 (Accession O88870) of 3rd extracellular loop
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: bestrophin 1
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