Product Description: Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA)[3].
Applications: Neuroscience-Neuromodulation
Formula: C8H14Cl2N2
References: [1]Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3./[2]Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54./[3]Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.
CAS Number: 5579-84-0
Molecular Weight: 209.12
Compound Purity: 99.82
Research Area: Endocrinology; Inflammation/Immunology; Neurological Disease
Solubility: DMF : 5 mg/mL (ultrasonic)/DMSO : 33.33 mg/mL (ultrasonic)/H2O : ≥ 50 mg/mL
Target: Histamine Receptor
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