BI-9564, CAS 1883429-22-8

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CAS Number: 1883429-22-8

Description: BI-9564 inhibits BRD9 and BRD7 bromodomains and exhibits no significant off-target pharmacology against a panel of 324 kinases and 55 GPCRs at concentrations less than 5 µM. BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC₅₀s = 75 nM and 3.4 µM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 µM and 1 µM, respectively. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo.

Format: Solid

Storage Stability: At least 6 months at -20°C. 

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• SKU: BPS82064
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 82064
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK