Conjugation: Biotin
Description of Target: Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) (CCL5) is a proinflammatory chemokine that induces migration and activation of leukocytes, as well as implication in HIV infection. It binds to cell surface receptors CCR1, CCR3, CCR4, and CCR5. Its biological effects on leukocyte activation and HIV infection displays dependence on concentration and on the binding of cell surface glycosaminoglycans.
Key Reference: 1. "RANTES: a versatile and controversial chemokine"
Appay V., Rowland-Jones S.L.
Trends Immunol 22:83-87 (2001)
2. "Identification of RANTES, MIP-1, and MIP-1[1] as the major HIV-suppressive factors produced by CD8+T cells"
Cocchi F., De Vico A.L., Garzino-Demo A., Arya S.K., Gallo R.C., Lusso P.
Science 270:1811-1815 (1995)
3. A human T cell-specific molecule is a member of a new gene family
Schall T.J., Jongstra J., Dyer B.J., Jorgensen J., Clayberger C., Davis M.M., Krensky A.M.
J Immunol 141:1018-1025 (1988)
4. "Engineering the glycosaminoglycan-binding affinity, kinetics and oligomerization behavior of RANTES: a tool for generating chemokine-based glycosaminoglycan antagonists"
Brandner B., Rek A., Diedrichs-Möhring M., Wildner G., Kungl A.J.
Protein Eng Des Sel. 22:367-373 (2009)
Product Format: Lyophilized
Purity: > 97% as determined by SDS-PAGE
Source: E. coli
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