BLX3887, CAS 934758-70-0

Shelf life (days): 730.0

Formulation: A crystalline solid

Formal Name: 4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide

Purity: ≥95%

Formula Markup: C10H5Cl3FN3O

Formula Weight: 308.522823

CAS Number: 934758-70-0

Notes: BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).{35444} It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 µM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.

• SKU: CAY27391-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27391-10
• Package Unit: 10 mg
• Quantity Unit: STK