BML-278, CAS 120533-76-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

Purity: ≥95%

Formula Markup: C24H25NO4

Formula Weight: 391.5

CAS Number: 120533-76-8

Notes: BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.{34113} It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively).{34113} BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA (Item No. 10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.{34113}

• SKU: CAY20209-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20209-5
• Package Unit: 5 mg
• Quantity Unit: STK