BMS-1166, CAS 1818314-88-3

Product Description: BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2].

Applications: Cancer-programmed cell death

Formula: C36H33ClN2O7

References: [1]Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867./[2]Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.

CAS Number: 1818314-88-3

Molecular Weight: 641.11

Compound Purity: 99.41

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: PD-1/PD-L1

• SKU: MEXHY-102011-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-102011-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK