Product Description: BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].
Applications: Neuroscience-Neuromodulation
Formula: C33H42N4O6
References: [1]Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32./[2]Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82.
CAS Number: 186185-03-5
Molecular Weight: 590.71
Compound Purity: 99.08
Research Area: Neurological Disease; Endocrinology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Neuropeptide Y Receptor
English
Deutsch
