BMS 833923, CAS 1059734-66-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide

Purity: ≥98%

Formula Markup: C30H27N5O

Formula Weight: 473.6

CAS Number: 1059734-66-5

Notes: Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors.{21774} BMS 833923 is an orally bioavailable inhibitor of Smo.{27708,27709} It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

• SKU: CAY16240-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16240-50
• Package Unit: 50 mg
• Quantity Unit: STK