Formulation: A solid
Formal Name: (6S)-5,6-dihydro-4-(4-methylphenyl)-3-(2H-tetrazol-5-yl)-6-[4-(4,4,4-trifluorobutoxy)phenyl]-6-(trifluoromethyl)-2(1H)-pyridinone
Purity: ≥98%
Formula Markup: C24H21F6N5O2
Formula Weight: 525,4
Shelf life (days): 1460
CAS Number: 1441057-15-3
Notes: BMS 963272 is an inhibitor of monoacylglycerol acyltransferase 2 (MGAT-2; IC50 = 7.1 nM).{64146} It is selective for MGAT-2 over MGAT-3, acyl-CoA wax alcohol acyltransferase 2 (AWAT2), and diacylglycerol acyltransferase 2 (DGAT-2; IC50s = >33 µM for all). In vivo, BMS 963272 (30 mg/kg) reduces body weight gain and food intake in a wild-type but not Mogat2-/- mouse model of high-fat diet-induced obesity. BMS 963272 (0.3 and 3 mg/kg) reduces plasma alanine transaminase (ALT), aspartate aminotransferase (AST), and bile acid levels and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a choline-deficient and high-fat diet (CDAHFD).{65912}
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