Product Description: BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM[1][2].
Applications: Neuroscience-Neurodegeneration
Formula: C18H22F2N4O
References: [1]Paquette MA, et al. The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology (Berl). 2009 Jul;204(4):743-54. /[2]Paquette MA, et al. Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Neuroreport. 2008 Jan 8;19(1):111-5.
CAS Number: 105565-56-8
Molecular Weight: 348.39
Compound Purity: 98.96
Research Area: Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target: 5-HT Receptor;Adrenergic Receptor;Sigma Receptor
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