Product Description: BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C31H31NO8
References: [1]Portoghese PS, et al. A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. Eur J Pharmacol. 1992;218(1):195-196. /[2]House RV, et al. Suppression of immune function by non-peptidic delta opioid receptor antagonists. Neurosci Lett. 1995 Sep 29;198(2):119-22./[3]Miyata Y, et al. Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4710-2.
CAS Number: 864461-31-4
Molecular Weight: 545.58
Research Area: Neurological Disease
Target: Opioid Receptor
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