Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-(phenyl-d5)propane-1,2-diyl))tris(pyrazine-2-carboxamide)
Purity: ≥99% deuterated forms (d1-d15)
Formula Markup: C57H54D15B3N12O9
Formula Weight: 1113.75714
Notes: Bortezomib-d15 is intended for use as an internal stadard for the quantification of bortezomib (Item No. 10008822) by GC- or LC-MS. When stored as a lyophilized solid, bortezomib exists as in a trimeric boroxine form but exists as the free boronic acid in solution.{43920} Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM).{29274} It binds the β5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity.{29723,29722,28244} Bortezomib blocks the degradation of tumor-suppressing and proapoptotic proteins to induce cell cycle arrest and apoptosis in cancer cell lines.{29274,29725}
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