Bosutinib-d8

Product Description: Bosutinib-d8 is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[1][2].

Applications: Cancer-Kinase/protease

Formula: C26H21D8Cl2N5O3

References: [1]Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977./[2]Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381.

Molecular Weight: 538.50

Compound Purity: 99.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Autophagy;Bcr-Abl;Isotope-Labeled Compounds;Src

• SKU: MEXHY-10158S-500UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10158S-500UG
• Package Unit: 500 μg
• Quantity Unit: STK