Product Description: Brigimadlin intermediate-1 is an intermediate of the E3 ubiquitin protein ligase MDM-2 inhibitor Brigimadlin (HY-152859) and can be used to synthesize Antibody-Drug Conjugates (ADCs) .
Applications: Cancer-programmed cell death
Formula: C9H10N2O4
References: [1]Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13./[2]WHO Drug Information-World Health Organization (WHO)./[3]Hao X, et al. BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models. Neuro Oncol. 2023 May 4;25(5):913-926.
CAS Number: 1149388-04-4
Molecular Weight: 210.19
Research Area: cancer
Solubility: 10 mM in DMSO
Target: Drug Intermediate
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