Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N,N,2-trimethyl-5-nitro-benzenesulfonamide
Purity: ≥98%
Formula Markup: C9H12N2O4S
Formula Weight: 244.3
CAS Number: 433695-36-4
Notes: BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM.{27633} It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5.{27633} Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram (Item No. 10011132) on monocytes, lung macrophages, and CD8+ T-lymphocytes.{27633} BRL 50481, at 30 µM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B.{27635} BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.{27634}
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