BX-912, CAS 702674-56-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

Purity: ≥98%

Formula Markup: C20H23BrN8O

Formula Weight: 471.4

CAS Number: 702674-56-4

Notes: 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC.{24210} BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM).{24213} It less effectively inhibits a panel of related serine-threonine kinases.{24213} BX-912 has been used to evaluate the role of PDK1 in kinase activation and cell survival.{23909,24212,24211}

• SKU: CAY14708-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14708-5
• Package Unit: 5 mg
• Quantity Unit: STK