C-021 (Standard), CAS 864289-85-0

Product Description: C-021 (Standard) is the analytical standard of C-021. This product is intended for research and analytical applications. C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].

Formula: C27H41N5O2

References: [1]Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17(1):64-73./[2]Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.

CAS Number: 864289-85-0

Molecular Weight: 467.65

Research Area: Inflammation/Immunology

Target: CCR;Reference Standards

• SKU: MEXHY-103364R-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103364R-0
• Package Unit: Get quote
• Quantity Unit: STK