C-176, CAS 314054-00-7

Product Description: C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].

Applications: COVID-19-immunoregulation

Formula: C11H7IN2O4

References: [1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273./[2]Zhang LM, et al. STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury. J Neurochem. 2022 Sep;162(5):444-462.

CAS Number: 314054-00-7

Molecular Weight: 358.09

Compound Purity: 99.45

Research Area: Inflammation/Immunology

Solubility: DMSO : 62.5 mg/mL (ultrasonic)/Ethanol : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)

Target: STING

• SKU: MEXHY-112906-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112906-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK