C1s-IN-1 (trihydrochloride), CAS 1376162-36-5

Product Description: C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1].

Formula: C16H22Cl3N5

References: [1]Xu X, et al., Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212(4):689-701.

CAS Number: 1376162-36-5

Molecular Weight: 390.74

Compound Purity: 97.42

Research Area: Inflammation/Immunology

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Complement System

• SKU: MEXHY-W371165-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W371165-25
• Package Unit: 25 mg
• Quantity Unit: STK