CA77.1, CAS 2412270-22-3

Product Description: CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research[1].

Applications: Cancer-programmed cell death

Formula: C16H12ClN3O

References: [1]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell. 2021 May 13;184(10):2696-2714.e25.

CAS Number: 2412270-22-3

Molecular Weight: 297.74

Compound Purity: 99.98

Research Area: Neurological Disease

Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)/Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Autophagy

• SKU: MEXHY-134923-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-134923-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK