Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[(1S)-1-[[(1-formyl-2-phenylethyl)amino]carbonyl]-2-methylpropyl]-carbamic acid, phenylmethyl ester
Purity: ≥95%
Formula Markup: C22H26N2O4
Formula Weight: 382.5
CAS Number: 88191-84-8
Notes: The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates.{13816} Calpain Inhibitor III is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2).{22713} Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia.{22714} Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.{22712}
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