Product Type: Inhibitor
CAS No.: 59721-29-8
MolecularFormula: C20H22N4O5·CH3SO3H
Molecular Weight: 494,5
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (50 mg/mL) or Water (50mg/mL)
Appearance: Off-white powder
PubChem CID: 5284360
Scientific Background: Camostat mesylate is an orally active protease inhibitor. It inhibits the serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (Covid-19) into lung cells and Human coronavirus NL63 into HeLa cells. It has also been used in some cancer treatments, against viral infections, and for inhibiting fibrosis in liver, kidney disease and pancreatitis.
References: 1. Okuno M., et al. (2002). Front Biosci. 7 (4): d204-218. 2. Hsieh H. P., Hsu, J. T. (2007). Current Pharmaceutical Design. 13 (34): 3531–3542. 3. Kitamura K., Tomita K. (2012). Clinical and Experimental Nephrology. 16 (1): 44–48. 4. Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. (2012) J Virol. 86(12): 6537-6545. 5.. Hoffman M., et al. (2020) Cell: https://doi.org/10.1016/j.cell.2020.02.052
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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