Target Synonym: CA12;CA-XII;CAXII;HsT18816;T18816;FLJ20151
Background: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.
Immunogen: Recombinant Human Carbonic Anhydrase XII/CA12 protein
Buffer: 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0
Dilution: ICC/IF 1:20-1:100
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