Product Description: Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
Applications: COVID-19-immunoregulation
Formula: C12H17N3O3S
References: [1]Teshima Y, et al. Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation. 2003 Nov 4;108(18):2275-81./[2]Chang HB, et al. Na(+)/H(+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide. Exp Neurol. 2015 Oct;272:11-6./[3]O'Donnell ME, et al. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb;33(2):225-34.
CAS Number: 159138-80-4
Molecular Weight: 283.35
Compound Purity: 99.89
Research Area: Inflammation/Immunology; Cardiovascular Disease; Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: Na+/H+ Exchanger (NHE)
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