Caveolin 1 blocking peptide

Species: Human

Specificity/Sensitivity: The peptide was used in the production of GTX89541.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservative.

Background: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Region Sequence: C-DELSEKQVYDAH

Full Name: caveolin 1

• SKU: GTX89541-PEP-100
• Manufacturer: GeneTex
• Manufacturer SKU: GTX89541-PEP-100
• Package Unit: 100 μg
• Quantity Unit: STK
• Human Gene ID: 857