CAY10526, CAS 938069-71-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-(benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one

Purity: ≥98%

Formula Markup: C12H7BrO3S

Formula Weight: 311.1

CAS Number: 938069-71-7

Notes: Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1).{11266,12923,11537} CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 µM without any effect on COX-2 expression.{14793}

• SKU: CAY10010088-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10010088-1
• Package Unit: 1 mg
• Quantity Unit: STK