CBR-5884, CAS 681159-27-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid, ethyl ester

Purity: ≥98%

Formula Markup: C14H12N2O4S2

Formula Weight: 336.4

CAS Number: 681159-27-3

Notes: CBR-5884 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 33 µM.{30606} It does not affect other NAD+-dependent dehydrogenases, including lactate dehydrogenase and malate dehydrogenase 1. CBR-5884 inhibits the proliferation of cancer cells by blocking de novo serine synthesis and is selectively cytotoxic for cells with high serine biosynthetic activity.{30606}

• SKU: CAY19236-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19236-1
• Package Unit: 1 mg
• Quantity Unit: STK