CCG-50014, CAS 883050-24-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione

Purity: ≥98%

Formula Markup: C16H13FN2O2S

Formula Weight: 316.3

CAS Number: 883050-24-6

Notes: CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins.{19235} RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins.{19235} CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα0, while blocking GTPase activity and Gα0-dependent translocation of RGS4 to the membrane.{19235}

• SKU: CAY10802-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10802-1
• Package Unit: 1 mg
• Quantity Unit: STK