Product Description: CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity.
Applications: Cancer-Kinase/protease
Formula: C18H20ClN5
References: [1]Yap TA et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71./[2]Wang FZ, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014;103:118-125.
CAS Number: 885499-61-6
Molecular Weight: 341.84
Compound Purity: 99.69
Research Area: Cancer
Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Akt;Apoptosis;Autophagy
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