CCT251545, CAS 1661839-45-7

Product Description: CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells[1]. CCT251545 is a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease[2].

Applications: Cancer-Kinase/protease

Formula: C23H24ClN5O

References: [1]Mallinger A, et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J Med Chem. 2015 Feb 26;58(4):1717-35./[2]Dale T, et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol. 2015 Dec;11(12):973-980.

CAS Number: 1661839-45-7

Molecular Weight: 421.92

Compound Purity: 99.39

Research Area: Cancer

Solubility: DMSO : ≥ 50 mg/mL

Target: Wnt

• SKU: MEXHY-12681-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12681-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK