Clone Name: 9X23
Application Note: WB: 1:500 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 104
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 500 μg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Uniprot ID: P40189
Antigen Species: Human
Immunogen: Human recombinant gp130
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: interleukin 6 signal transducer
English
Deutsch
