Target Synonym: MCAM; CD146; MUC18; cell surface glycoprotein MUC18
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human CD146/MCAM
Dilution: WB 1:500-1:2000
Calculated MW: 57kDa/71kDa
Observed MW: 120KDa
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