Clone: 11G5a
Description of Target: MOUSE ANTI HUMAN CD151
Key Reference: 1. Yauch, R.L. et al. (1998) Highly stoichiometric, stable, and specific association of integrin alpha 3 beta 1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol. Cell. Biol. 9: 2751-2765.
2. Crew, V.K. et al. (2004) CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 104:2217-2223.
3. Zheng, Z. and Liu, Z. (2006) CD151 gene delivery activates PI3K/Akt pathway and promotes neovascularization
Product Format: Liquid. Phosphate buffered saline
Protein Name: CD151 antigen
Protein Size: 253
Purification: Protein G Purified
Specificity#: Mouse anti Human CD151 antibody, clone 11G5a recognizes the human CD151 cell surface antigen, also known as PETA-3. CD151 is expressed by epithelial cells, endothelial cells, platelets, megakaryocytes, monocytes and in the renal glomeruli and proximal and distal tubules. CD151 is not expressed by lymphocytes or granulocytes. More recently CD151 has also been shown to be expressed by erythrocytes, and to carry the MER2 blood group antigen (Crew et al. 2004).
It should be noted that CD151 is very closely associated with the alpha3 beta1 integrin in cells and co-immunoprecipitation may occur even in quite stringent conditions (Yauch. et al. 1998).
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