Clone Name: KD1
Application Note: FACS: 1:25-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 29/26
Specificity/Sensitivity: Clone KD1 recognizes both forms of CD16 and will therefore recognize all cell types expressing CD16.,We do not recommend use of this product for Dog,Rat.
Form: Liquid
Buffer (with preservative): PBS, 0.09% Sodium Azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot ID: P08637/O75015
Antigen Species: Human
Immunogen: A polyclonal population of NK cells.
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: Fc fragment of IgG receptor IIIa/Fc fragment of IgG receptor IIIb
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