Target Synonym: CVID;B-lymphocyteantigenCD;B-lymphocyte antigen CD;T-cellsurfaceantigenLeu;Differentiation antigen CD;T-cell surface antigen Leu;B-lymphocytesurfaceantigenB;B-lymphocyte surface antigen B;B4;CVID3;CD19;B-lymphocyteantigenCD19;B-lymphocytesurfaceantigenB4;T-cellsurfaceantigenLeu-12;B-lymphocyte antigen CD19;B-lymphocyte surface antigen B4;Differentiation antigen CD19;T-cell surface antigen Leu-12;B4;CVID3;CD19;CD19 molecule
Background: CD19 protein is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses . CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker . It is required for the responsiveness of mature B cell to antigen stimulation, germinal center development, and antibody affinity maturation . The CD19 protein associates with the B cell antigen receptor (BCR), CD81, CD38, CD21, CD22, and IFITM1/CD225/Leu13. These associations enable CD19 to amplify B cell signaling and reduce the threshold for antigen stimulation through the BCR.
Immunogen: A synthetic peptide corresponding to the N-terminus of the Human CD19
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:50-1:200;
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