CD26(202-36), CF740 conjugate, 0.1mg/mL

Description: Recognizes a glycoprotein of 110 kDa, identified as CD26 (Workshop VI; Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this MAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: 202-36

Immunogen: Human T cell clone

Antibody Reactivity: CD26

References: Note: References for this clone sold by other suppliers may be listed for expected applications.

1. Cancer Res (2005) 65(15): 6950-6. (functional studies)
2. J Biol Chem (2001) 276(22): 19532-19539. (Flow)
3. BMC Cancer (2011) 11:51. (IF)

Entrez Gene ID: 1803

Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)

Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)

Antibody Application Notes: Immunohistology Frozen Only 0.5-1.0 ug/mL/Immunofluorescence 0.5-1 ug/mL/Flow Cytometry 0.5-1 ug/million cells/0.1 mL/Does not react with pig or sheep, others not tested/Optimal dilution for a specific application should be determined by user

• SKU: BTMBNC740888-100
• Manufacturer: Biotium
• Manufacturer SKU: BNC740888-100
• Package Unit: 100 uL
• Quantity Unit: STK
• Reactivity: Human, Rat (Rattus)
• Clonality: Monoclonal
• Application: Immunofluorescence, Flow Cytometry, Functional Studies
• Isotype: IgG2b kappa
• Host: Mouse
• Conjugate: Conjugated, CF740