Description: This antibody recognizes a 67 kDa transmembrane protein which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Note that this MAb is not suitable for frozen tissues.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: B-B8
Immunogen: T cells activated with PHA
Antibody Reactivity: CD5
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Inf Immunity (1996) 64(5): 1595-1599. (cell depletion)
- Br J Haematol (2013) 163: 182-193. (antibody internalization)
Entrez Gene ID: 921
Expected AB Applications: Flow (surface) (expected)/Functional studies (published for clone)/IF (expected)
Z-Antibody Applications: Functional studies (published)/Flow, surface (expected)/IF (expected)
Antibody Application Notes: Not suitable for frozen tissues/Flow cytometry: 0.5-1 ug/million cells/Immunofluorescence: 0.5-1 ug/mL/Optimal dilution for a specific application should be determined by user
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