Description: Recognizes an 85-115 kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: 15,2
Immunogen: Human monocytes.
Antibody Reactivity: CD54/ICAM-1
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- J Leukocyte Biol (1998) 64: 519. (Flow, surface)
Inv Ophthalmol Visual Sci (2003) 44: 1888-1896. (IHC, frozen)Blood (1999) 93(11): 3723-3735. (IF)J Cell Biol (1992) 116(6): 1527-1535. (functional studies)
Entrez Gene ID: 3383
Expected AB Applications: IHC (frozen) (published for clone)/Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IF (published)/IHC, frozen (published)
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