Target Synonym: MLA;LAMP;Tetraspanin;CD antigen CD;Melanoma-associated antigen ME;Lysosomal-associated membrane protein;CD63;LAMP-3;ME491;MLA1;OMA81H;TSPAN30;CD63 antigen;CD antigen CD63;CD63 molecule;Granulophysin;Lysosomal-associated membrane protein 3;Melanoma-associated antigen ME491;Ocular melanoma-associated antigen;Tetraspanin-30;Tspan-30;LIMP;MLA1;LAMP-3;CD 63;CD63 antigen (melanoma 1 antigen);CD63 antigen melanoma 1 antigen;gp55;LAMP 3;LAMP3;Lysosomal associated membrane protein 3;Lysosome associated membrane glycoprotein 3;Mast cell antigen AD1;Melanoma 1 antigen;Melanoma associated antigen ME491;Melanoma associated antigen MLA1;MGC72893;MLA 1;NGA;Ocular melanoma associated antigen;PTLGP40;Tetraspanin 30;Tspan 30
Background: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Immunogen: Recombinant Human CD63 / Tspan-30 / Tetraspanin-30 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:20-1:100;FCM 1:25-1:100;
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