Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid, methyl ester
Purity: ≥98%
Formula Markup: C32H43NO4
Formula Weight: 505.7
CAS Number: 218600-53-4
Notes: The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.11 nM.{9897,20969} It induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells through inhibition of IκBα kinase/NF-κB signaling.{21755,21758} CDDO methyl ester has potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice and in Leprdb/db mice and triggering AMP-activated protein kinase and LKB1 activation in muscle and liver.{21757}
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