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Encompassing Amino Acids: CDK12: 658-1490(end) Cyclin K: 2-580(end)
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay was done according to CDK12/Cyclin K Kinase Assay Kit (BPS Bioscience #78298) with CDK12/Cyclin K titrated from 4000 ng/rxn to 0 ng/rxn.
Description: Complex of CDK19 and Cyclin proteins. The two proteins are co-expressed and affinity purified.Recombinant human CDK1 (cyclin dependent kinase 12), encompassing amino acids 658-1490(end). This construct contains an N-terminal GST-tag and includes a Thrombin Cleavage Site to facilitate removal of the GST portion. The recombinant protein was affinity purified.Recombinant human Cyclin K (CCNK), full length, encompassing amino acids 2-580(end). This construct contains an N-terminal GST-tag and includes a Thrombin Cleavage Site to facilitate removal of the GST portion. The recombinant protein was affinity purified.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT
Genbank: CDK12: NM_016507 Cyclin K: NM_001099402
Purity: ≥80%
Tags: N-terminal GST-tags
Uniprot: CDK12: Q9NYV4 Cyclin K: O75909
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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