Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[5-[4-(methyl-d3)phenyl-2,3,5,6-d4]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C17H7D7F3N3O2S
Formula Weight: 388.4
CAS Number: 544686-21-7
Notes: Celecoxib-d7 is intended for use as an internal standard for the quantification of celecoxib (Item No. 10008672) by GC- or LC-MS. Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively).{11633,8926} It displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition.{12660,11712,13638} Formulations containing celecoxib have been used in the treatment of inflammation while circumventing the gastrointestinal toxicity associated with traditional non-sterodial anti-inflammatory drugs, however, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events.{14766}
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