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Applications: Useful for screening and validating antibodies against CD123 and CD123 CAR-T for immunotherapy research and drug discovery. Also useful for CD123 binding assays to screen for CD123 ligands.
Background: CD123, also known as interleukin 3 receptor alpha (IL3Ra), is a transmembrane protein normally expressed on basophils and plasmacytoid dendritic cells and overexpressed on multiple blood cancers and leukemic hematopoietic stem cells. It normally plays a role in cell proliferation. CAR-Ts and other therapies targeting CD123 are currently being evaluated in clinical trials. CD123 may be especially valuable in treating B cell acute lymphoblastic leukemia patients who have relapsed after CD19 CAR-T treatment.
Description: Stable, recombinant clonal CHO cell line constitutively expressing full length human CD123 protein (Genbank #NM_002183.2). Surface expression of CD123 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD123 expression to mimic different stages of cancer target cells with various CD123 expression levels.
Host Cell Line: CHO
Mycoplasma Testing: This cell line has been screened using the Quick Test Mycoplasma Detection Kit (Biotool.com, #B39032) to confirm the absence of mycoplasma contamination.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of FBS + 10% DMSO.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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