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Applications: Screen for activators or inhibitors of antibody-mediated signaling for immunotherapy research and drug discovery.
Characterize FAP antibodies and ligands in binding assays.
Background: Fibroblast activation protein alpha (FAP-alpha) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family and is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP expression under physiological conditions is scarce in healthy adult tissues. But FAP gene is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has also been proposed as a molecular target of cancer therapies, and a great deal of research has gone into design and testing of diverse FAP-targeted treatments.
Description: Recombinant FAP-CHO K1 cell line stably expressing a full length human FAP-alpha protein (Genbank accession No: NM004460.2). Surface expression of FAP was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of FAP expression (High, Medium, or Low) to mimic different stages of cancer target cells with various FAP expression levels.
Genbank: NM004460.2
Host Cell Line: CHO-K1
Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, #LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Lonza, #LT07-518) was used as a positive control.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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