cGAS Inhibitor Screening Assay Kit

Shelf life (days): 180.0

Assay Range: 4.6-10,000 pM

Sensitivity: 48.4 pM

Formula Weight: 0.0

Notes: Cayman’s cGAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human cGAS, which is a cytosolic dsDNA sensor that detects microbial pathogens. The assay directly measures 2’3’-cGAMP produced by cGAS in the presence of DNA, ATP, and GTP. The cyclic dinucleotide product of that reaction is quantified via ELISA using a 2’3’-cGAMP-specific antiserum. The cGAS inhibitor CU-76 is included as a positive control. The ELISA portion of Cayman’s cGAS Inhibitor Screening Assay Kit is a competitive assay with a range of 4.57-10,000 pM, a midpoint of approximately 300 pM (50% B/B0), and a sensitivity (80% B/B0) of approximately 50 pM.

• SKU: CAY701930-96
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 701930-96
• Package Unit: 96 Well
• Quantity Unit: PAK
• Application: ELISA