CGP 37157, CAS 75450-34-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Purity: ≥95%

Formula Markup: C15H11Cl2NOS

Formula Weight: 324.2

CAS Number: 75450-34-9

Notes: CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 μM in isolated mitochondria).{25544} It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum.{25544} CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis.{25548,25547} CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 μM).{25545,25546}

• SKU: CAY15611-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15611-50
• Package Unit: 50 mg
• Quantity Unit: STK