CGP 57380, CAS 522629-08-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

Purity: ≥95%

Formula Markup: C11H9FN6

Formula Weight: 244.2

CAS Number: 522629-08-9

Notes: CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 μM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.{17271} It blocks the phosphorylation of eIF4E in response to TNF-α, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 = 3 μM).{17271} CGP 57380 also dose-dependently inhibits TNF-α production in RAW 264.7 cells that have been co-treated with agonists for Toll-like receptor (TLR)2 (HKLM), TLR4 (LPS), TLR6/2 (FSL), TLR7 (imiquimod), or TLR9 (CpG DNA), presumably by inhibiting MNK1.{17272}

• SKU: CAY13322-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13322-10
• Package Unit: 10 mg
• Quantity Unit: STK