Product Description: CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. [1][2].
Applications: Cancer-Kinase/protease
Formula: C13H8ClN5O
References: [1]Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55(3):PL61-5./[2]Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91./[3]Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15(5):524-32.
CAS Number: 104615-18-1
Molecular Weight: 285.69
Compound Purity: 99.96
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 12.22 mg/mL (ultrasonic)
Target: Adenosine Receptor;PI3K
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