Chaetocin, CAS 28097-03-2

Product Description: Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM.

Applications: Cancer-programmed cell death

Formula: C30H28N6O6S4

References: [1]Greiner D, et al. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol. 2005 Aug;1(3):143-5./[2]Tibodeau JD, et al. The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase. Antioxid Redox Signal. 2009 May;11(5):1097-106.

CAS Number: 28097-03-2

Molecular Weight: 696.84

Compound Purity: 99.58

Research Area: Cancer; Infection

Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Antibiotic;Bacterial;Histone Methyltransferase

• SKU: MEXHY-N2019-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N2019-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK